Liver Complex

Ochsengalle wirkt ähnlich wie das in Deutschland nicht erhältliche Tudca, Du bekommst pro Portion 750mg! Es soll zu einem verbesserten Gallenfluss führen, was Toxine besser aus der Leber ausleitet. Diese wird dadurch stärker entlastet und regeneriert somit schneller.

Auch Gallensteine sollen durch diese zerstört werden können. Ebenfalls Cholesterin wird über den Stuhlgang dadurch ausgeschieden.

Ohne ausreichend Galle werden Fette nicht richtig verdaut, was zu Gallenproblemen führt.1, 2, 3, 4, 6, 7, 8, 9, 10, 11, 12

Schisandra Extrakt hat im Livercomplex mehrere Einsatzgebiete. Es bietet als starkes Antioxidans eine protektive Wirkung & kann gleichzeitig die Menge der gebildeten Cytochrome stark vermehren. Dadurch können Toxine als auch Dinge wie Östrogen besser verstoffwechselt werden. Auch bei einer Fettleber könnte Schisandra Extrakt unterstützend wirken. 13, 14, 15, 16

Katuka oder Kutki kommt aus der Ayurveda und wird seit langer Zeit gegen Leberprobleme eingesetzt. Neben der Verbesserung der Leberaktivität führt Kutki zu einer Anregung der eigenen Gallenflüssigkeit. Dadurch kann es nachhaltig die Leberfunktion verbessern. Um Gallenflüssigkeit zu bilden, verbraucht dieses Cholesterin.17

Mariendistel bzw. Silymarin ist bekannt für seine protektive Eigenschaft auf die Leber. So verbessert es sowohl die Leberenzyme als auch die Funktion der Leber.18

Ingwer bietet eine Reihe an positiven Eigenschaften, die stark gegen Leberprobleme helfen können. Ingwer reduziert Leberbelastung, Cholesterin, Insulinresistenz und dient als starkes Antioxidans.19, 20

Hebt ebenfalls Cytochrome an und verbessert somit die Leberfunktion

Hilft deutlich bei dem Östrogenmetabolismus. Studien zeigen, dass DIM die Umwandlung von Testosteron zu Östrogen senken könnten.21

Es erhöht ebenfalls die Cytochrom Menge und sorgt für eine verbesserte Leberfunktion.22

1

https://www.pnas.org/doi/full/10.1073/pnas.0600780103

2

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4091928/

3

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3676171/

4

https://www.sciencedirect.com/science/article/abs/pii/S1569258297800207

5

https://pubmed.ncbi.nlm.nih.gov/9989105/

6

https://www.jbc.org/article/S0021-9258(18)75615-9/fulltext

7

https://www.jlr.org/article/S0022-2275(20)30141-3/fulltext

8

https://aasldpubs.onlinelibrary.wiley.com/doi/full/10.1002/hep.24107

9

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1419617/

10

https://www.sciencedirect.com/science/article/abs/pii/S0270913903000417

11

http://europepmc.org/article/med/6896227

12

https://www.thieme-connect.com/products/ejournals/abstract/10.1055/s-2004-813059

13
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5378736/#Sec9title

14
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3901324/

15
https://pubmed.ncbi.nlm.nih.gov/29173646/

16

99.^Pu HJ, Cao YF, He RR, Zhao ZL, Song JH, Jiang B, Huang T, Tang SH, Lu JM, Kurihara HCorrelation between Antistress and Hepatoprotective Effects of Schisandra Lignans Was Related with Its Antioxidative Actions in Liver CellsEvid Based Complement Alternat Med.(2012)

100.^Pao TT, Liu KT, Hsu HF, Sung CYStudies on Fructus schizandrae. I. Its effect on increased SGPT levels in animals caused by hepatotoxic chemical agentsZhonghua Yi Xue Za Zhi.(1974 May)

101.^Diphenyl Dimethyl Bicarboxylate in the Treatment of Viral Hepatitis, Adjuvant or Curative?.()

102.^A Novel Antihepatitis Drug, Bicyclol, Prevents Liver Carcinogenesis in Diethylnitrosamine-Initiated and Phenobarbital-Promoted Mice Tumor Model.()

103.^Bao L, Abe K, Tsang P, Xu JK, Yao XS, Liu HW, Kurihara HBilberry extract protect restraint stress-induced liver damage through attenuating mitochondrial dysfunctionFitoterapia.(2010 Dec)

104.^Ip SP, Mak DH, Li PC, Poon MK, Ko KMEffect of a lignan-enriched extract of Schisandra chinensis on aflatoxin B1 and cadmium chloride-induced hepatotoxicity in ratsPharmacol Toxicol.(1996 Jun)

105.^Cyong JC, Ki SM, Iijima K, Kobayashi T, Furuya MClinical and pharmacological studies on liver diseases treated with Kampo herbal medicineAm J Chin Med.(2000)

106.^Ip SP, Poon MK, Che CT, Ng KH, Kong YC, Ko KMSchisandrin B protects against carbon tetrachloride toxicity by enhancing the mitochondrial glutathione redox status in mouse liverFree Radic Biol Med.(1996)

107.^Chiu HF, Chen TY, Tzeng YT, Wang CKImprovement of Liver Function in Humans Using a Mixture of Schisandra Fruit Extract and SesaminPhytother Res.(2012 May 21)

17

https://www.annualreviews.org/doi/full/10.1146/annurev.biochem.72.121801.161712

18

1.^Anton Gillessen, Hartmut H-J SchmidtSilymarin as Supportive Treatment in Liver Diseases: A Narrative ReviewAdv Ther.(2020 Apr)

2.^Abenavoli L, Capasso R, Milic N, Capasso FMilk thistle in liver diseases: past, present, futurePhytother Res.(2010 Oct)

3.^Abenavoli L, Bardazzi G, Cracolici F, Quaranta C, Santini G, Graziosi S, Polero L, Leggio L, Addolorato GComplementary therapies for treating alcoholism First Annual meeting by Complementary Medicine Research Group of the Italian Society for Alcohol Studies-May 5, 2006, Florence, ItalyFitoterapia.(2008 Feb)

4.^Pradhan SC, Girish CHepatoprotective herbal drug, silymarin from experimental pharmacology to clinical medicineIndian J Med Res.(2006 Nov)

5.^Kroll DJ, Shaw HS, Oberlies NHMilk thistle nomenclature: why it matters in cancer research and pharmacokinetic studiesIntegr Cancer Ther.(2007 Jun)

6.^Kim NC, Graf TN, Sparacino CM, Wani MC, Wall MEComplete isolation and characterization of silybins and isosilybins from milk thistle (Silybum marianum)Org Biomol Chem.(2003 May 21)

7.^Lee DY, Liu YMolecular structure and stereochemistry of silybin A, silybin B, isosilybin A, and isosilybin B, Isolated from Silybum marianum (milk thistle)J Nat Prod.(2003 Sep)

8.^Membranes and the setting of energy demand.()

9.^Kidd PMBioavailability and activity of phytosome complexes from botanical polyphenols: the silymarin, curcumin, green tea, and grape seed extractsAltern Med Rev.(2009 Sep)

10.^Sheu SY, Lai CH, Chiang HCInhibition of xanthine oxidase by purpurogallin and silymarin groupAnticancer Res.(1998 Jan-Feb)

11.^Pauff JM, Hille RInhibition studies of bovine xanthine oxidase by luteolin, silibinin, quercetin, and curcuminJ Nat Prod.(2009 Apr)

12.^Zhang S, Morris MEEffects of the flavonoids biochanin A, morin, phloretin, and silymarin on P-glycoprotein-mediated transportJ Pharmacol Exp Ther.(2003 Mar)

13.^Tyagi AK, Singh RP, Agarwal C, Chan DC, Agarwal RSilibinin strongly synergizes human prostate carcinoma DU145 cells to doxorubicin-induced growth Inhibition, G2-M arrest, and apoptosisClin Cancer Res.(2002 Nov)

14.^Maitrejean M, Comte G, Barron D, El Kirat K, Conseil G, Di Pietro AThe flavanolignan silybin and its hemisynthetic derivatives, a novel series of potential modulators of P-glycoproteinBioorg Med Chem Lett.(2000 Jan 17)

15.^Zhou S, Lim LY, Chowbay BHerbal modulation of P-glycoproteinDrug Metab Rev.(2004 Feb)

16.^Di Pierro F, Villanova N, Agostini F, Marzocchi R, Soverini V, Marchesini GPilot study on the additive effects of berberine and oral type 2 diabetes agents for patients with suboptimal glycemic controlDiabetes Metab Syndr Obes.(2012)

17.^Gurley BJ, Barone GW, Williams DK, Carrier J, Breen P, Yates CR, Song PF, Hubbard MA, Tong Y, Cheboyina SEffect of milk thistle (Silybum marianum) and black cohosh (Cimicifuga racemosa) supplementation on digoxin pharmacokinetics in humansDrug Metab Dispos.(2006 Jan)

18.^Ka SO, Kim KA, Kwon KB, Park JW, Park BHSilibinin attenuates adipogenesis in 3T3-L1 preadipocytes through a potential upregulation of the insig pathwayInt J Mol Med.(2009 May)

19.^Goldstein JL, DeBose-Boyd RA, Brown MSProtein sensors for membrane sterolsCell.(2006 Jan 13)

20.^Zhan T, Digel M, Küch EM, Stremmel W, Füllekrug JSilybin and dehydrosilybin decrease glucose uptake by inhibiting GLUT proteinsJ Cell Biochem.(2011 Mar)

21.^Nomura M, Takahashi T, Nagata N, Tsutsumi K, Kobayashi S, Akiba T, Yokogawa K, Moritani S, Miyamoto KInhibitory mechanisms of flavonoids on insulin-stimulated glucose uptake in MC3T3-G2/PA6 adipose cellsBiol Pharm Bull.(2008 Jul)

22.^Sonnenbichler J, Zetl IBiochemical effects of the flavonolignane silibinin on RNA, protein and DNA synthesis in rat liversProg Clin Biol Res.(1986)

23.^Song Z, Song M, Lee DY, Liu Y, Deaciuc IV, McClain CJSilymarin prevents palmitate-induced lipotoxicity in HepG2 cells: involvement of maintenance of Akt kinase activationBasic Clin Pharmacol Toxicol.(2007 Oct)

24.^Salamone F, Galvano F, Cappello F, Mangiameli A, Barbagallo I, Li Volti GSilibinin modulates lipid homeostasis and inhibits nuclear factor kappa B activation in experimental nonalcoholic steatohepatitisTransl Res.(2012 Jun)

25.^Saller R, Brignoli R, Melzer J, Meier RAn updated systematic review with meta-analysis for the clinical evidence of silymarinForsch Komplementmed.(2008 Feb)

26.^Jayaraj R, Deb U, Bhaskar AS, Prasad GB, Rao PVHepatoprotective efficacy of certain flavonoids against microcystin induced toxicity in miceEnviron Toxicol.(2007 Oct)

27.^Fausto N, Campbell JSMouse models of hepatocellular carcinomaSemin Liver Dis.(2010 Feb)

28.^Brandon-Warner E, Eheim AL, Foureau DM, Walling TL, Schrum LW, McKillop IHSilibinin (Milk Thistle) potentiates ethanol-dependent hepatocellular carcinoma progression in male miceCancer Lett.(2012 Dec 29)

29.^Bowe WP, Patel N, Logan ACAcne vulgaris: the role of oxidative stress and the potential therapeutic value of local and systemic antioxidantsJ Drugs Dermatol.(2012 Jun)

30.^ Sahib A, Al-Anbari H, Salih M, Abdullah FEffects of Oral Antioxidants on Lesion Counts Associated with Oxidative Stress and Inflammation in Patients with Papulopustular AcneJ Clin Exp Dermatol Res.(2012 Dec))

31.^Forinash AB, Yancey AM, Barnes KN, Myles TDThe use of galactogogues in the breastfeeding motherAnn Pharmacother.(2012 Oct)

32.^Low Dog TThe use of botanicals during pregnancy and lactationAltern Ther Health Med.(2009 Jan-Feb)

33.^Zapantis A, Steinberg JG, Schilit LUse of herbals as galactagoguesJ Pharm Pract.(2012 Apr)

34.^Di Pierro F, Callegari A, Carotenuto D, Tapia MMClinical efficacy, safety and tolerability of BIO-C (micronized Silymarin) as a galactagogueActa Biomed.(2008 Dec)

19

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6986243/

20

https://clinicaltrials.gov/ct2/show/NCT02289235

21

1.^Aggarwal BB, Ichikawa HMolecular targets and anticancer potential of indole-3-carbinol and its derivativesCell Cycle.(2005 Sep)

2.^Pappa G, Strathmann J, Löwinger M, Bartsch H, Gerhäuser CQuantitative combination effects between sulforaphane and 3,3'-diindolylmethane on proliferation of human colon cancer cells in vitroCarcinogenesis.(2007 Jul)

3.^Bradfield CA, Bjeldanes LFStructure-activity relationships of dietary indoles: a proposed mechanism of action as modifiers of xenobiotic metabolismJ Toxicol Environ Health.(1987)

4.^Grose KR, Bjeldanes LFOligomerization of indole-3-carbinol in aqueous acidChem Res Toxicol.(1992 Mar-Apr)

5.^De Kruif CA, Marsman JW, Venekamp JC, Falke HE, Noordhoek J, Blaauboer BJ, Wortelboer HMStructure elucidation of acid reaction products of indole-3-carbinol: detection in vivo and enzyme induction in vitroChem Biol Interact.(1991)

6.^McNaughton SA, Marks GCDevelopment of a food composition database for the estimation of dietary intakes of glucosinolates, the biologically active constituents of cruciferous vegetablesBr J Nutr.(2003 Sep)

7.^Shapiro TA, Fahey JW, Wade KL, Stephenson KK, Talalay PChemoprotective glucosinolates and isothiocyanates of broccoli sprouts: metabolism and excretion in humansCancer Epidemiol Biomarkers Prev.(2001 May)

8.^Conaway CC, Getahun SM, Liebes LL, Pusateri DJ, Topham DK, Botero-Omary M, Chung FLDisposition of glucosinolates and sulforaphane in humans after ingestion of steamed and fresh broccoliNutr Cancer.(2000)

9.^Shapiro TA, Fahey JW, Wade KL, Stephenson KK, Talalay PHuman metabolism and excretion of cancer chemoprotective glucosinolates and isothiocyanates of cruciferous vegetablesCancer Epidemiol Biomarkers Prev.(1998 Dec)

10.^Rouzaud G, Young SA, Duncan AJHydrolysis of glucosinolates to isothiocyanates after ingestion of raw or microwaved cabbage by human volunteersCancer Epidemiol Biomarkers Prev.(2004 Jan)

11.^Verkerk R, Dekker MGlucosinolates and myrosinase activity in red cabbage (Brassica oleracea L. var. Capitata f. rubra DC.) after various microwave treatmentsJ Agric Food Chem.(2004 Dec 1)

12.^Rungapamestry V, Duncan AJ, Fuller Z, Ratcliffe BChanges in glucosinolate concentrations, myrosinase activity, and production of metabolites of glucosinolates in cabbage (Brassica oleracea Var. capitata) cooked for different durationsJ Agric Food Chem.(2006 Oct 4)

13.^Song L, Thornalley PJEffect of storage, processing and cooking on glucosinolate content of Brassica vegetablesFood Chem Toxicol.(2007 Feb)

14.^Weng JR, Tsai CH, Kulp SK, Chen CSIndole-3-carbinol as a chemopreventive and anti-cancer agentCancer Lett.(2008 Apr 18)

15.^Aromatic hydrocarbon responsiveness-receptor agonists generated from indole-3-carbinol in vitro and in vivo: comparisons with 2,3,7,8-tetrachlorodibenzo-p-dioxin.()

16.^2,3,7,8-Tetrachlorodibenzo-p-dioxin and Diindolylmethanes Differentially Induce Cytochrome P450 1A1, 1B1, and 19 in H295R Human Adrenocortical Carcinoma.()

17.^Riby JE1, Feng C, Chang YC, Schaldach CM, Firestone GL, Bjeldanes LFThe major cyclic trimeric product of indole-3-carbinol is a strong agonist of the estrogen receptor signaling pathwayBiochemistry.(2000 Feb 8)

18.^Effects of dietary indole-3-carbinol on estradiol metabolism and spontaneous mammary tumors in mice.()

19.^Chang HP, Wang ML, Chan MH, Chiu YS, Chen YHAntiobesity activities of indole-3-carbinol in high-fat-diet-induced obese miceNutrition.(2011 Apr)

20.^Shin JH1, Zhang L, Murillo-Sauca O, Kim J, Kohrt HE, Bui JD, Sunwoo JBModulation of natural killer cell antitumor activity by the aryl hydrocarbon receptorProc Natl Acad Sci U S A.(2013 Jul 23)

21.^Marques M, Laflamme L, Benassou I, Cissokho C, Guillemette B, Gaudreau L1Low levels of 3,3'-diindolylmethane activate estrogen receptor α and induce proliferation of breast cancer cells in the absence of estradiolBMC Cancer.(2014 Jul 21)

22.^Selective Activation of Estrogen Receptor-β Target Genes by 3,3′-Diindolylmethane.()

23.^Lo R, Matthews JA new class of estrogen receptor beta-selective activatorsMol Interv.(2010 Jun)

24.^Leong H1, Riby JE, Firestone GL, Bjeldanes LFPotent ligand-independent estrogen receptor activation by 3,3'-diindolylmethane is mediated by cross talk between the protein kinase A and mitogen-activated protein kinase signaling pathwaysMol Endocrinol.(2004 Feb)

25.^Leong H1, Firestone GL, Bjeldanes LFCytostatic effects of 3,3'-diindolylmethane in human endometrial cancer cells result from an estrogen receptor-mediated increase in transforming growth factor-alpha expressionCarcinogenesis.(2001 Nov)

26.^Sanderson JT, Slobbe L, Lansbergen GW, Safe S, van den Berg M2,3,7,8-Tetrachlorodibenzo-p-dioxin and diindolylmethanes differentially induce cytochrome P450 1A1, 1B1, and 19 in H295R human adrenocortical carcinoma cellsToxicol Sci.(2001 May)

27.^Ah receptor agonists as endocrine disruptors: antiestrogenic activity and mechanisms.()

28.^Okino ST, Pookot D, Basak S, Dahiya RToxic and chemopreventive ligands preferentially activate distinct aryl hydrocarbon receptor pathways: implications for cancer preventionCancer Prev Res (Phila).(2009 Mar)

29.^Parkin DR, Lu Y, Bliss RL, Malejka-Giganti DInhibitory effects of a dietary phytochemical 3,3'-diindolylmethane on the phenobarbital-induced hepatic CYP mRNA expression and CYP-catalyzed reactions in female ratsFood Chem Toxicol.(2008 Jul)

30.^Wattenberg LW, Loub WDInhibition of polycyclic aromatic hydrocarbon-induced neoplasia by naturally occurring indolesCancer Res.(1978 May)

31.^Jellinck PH1, Forkert PG, Riddick DS, Okey AB, Michnovicz JJ, Bradlow HLAh receptor binding properties of indole carbinols and induction of hepatic estradiol hydroxylationBiochem Pharmacol.(1993 Mar 9)

32.^Estrogenic and antiestrogenic activities of 16α- and 2-hydroxy metabolites of 17β-estradiol in MCF-7 and T47D human breast cancer cells.()

33.^Sepkovic DW, Bradlow HL, Michnovicz J, Murtezani S, Levy I, Osborne MPCatechol estrogen production in rat microsomes after treatment with indole-3-carbinol, ascorbigen, or beta-naphthaflavone: a comparison of stable isotope dilution gas chromatography-mass spectrometry and radiometric methodsSteroids.(1994 May)

34.^Bradlow HL, Telang NT, Sepkovic DW, Osborne MP2-hydroxyestrone: the 'good' estrogenJ Endocrinol.(1996 Sep)

35.^Dalessandri KM1, Firestone GL, Fitch MD, Bradlow HL, Bjeldanes LFPilot study: effect of 3,3'-diindolylmethane supplements on urinary hormone metabolites in postmenopausal women with a history of early-stage breast cancerNutr Cancer.(2004)

36.^Fan S1, Meng Q, Xu J, Jiao Y, Zhao L, Zhang X, Sarkar FH, Brown ML, Dritschilo A, Rosen EMDIM (3,3'-diindolylmethane) confers protection against ionizing radiation by a unique mechanismProc Natl Acad Sci U S A.(2013 Nov 12)

37.^Kitagawa R1, Kastan MBThe ATM-dependent DNA damage signaling pathwayCold Spring Harb Symp Quant Biol.(2005)

38.^Goodarzi AA1, Jonnalagadda JC, Douglas P, Young D, Ye R, Moorhead GB, Lees-Miller SP, Khanna KKAutophosphorylation of ataxia-telangiectasia mutated is regulated by protein phosphatase 2AEMBO J.(2004 Nov 10)

39.^Kotsopoulos J1, Zhang S2, Akbari M1, Salmena L3, Llacuachaqui M2, Zeligs M4, Sun P2, Narod SA1BRCA1 mRNA levels following a 4-6-week intervention with oral 3,3'-diindolylmethaneBr J Cancer.(2014 Jul 15)

40.^Grubbs CJ1, Steele VE, Casebolt T, Juliana MM, Eto I, Whitaker LM, Dragnev KH, Kelloff GJ, Lubet RLChemoprevention of chemically-induced mammary carcinogenesis by indole-3-carbinolAnticancer Res.(1995 May-Jun)

41.^Le HT, Schaldach CM, Firestone GL, Bjeldanes LFPlant-derived 3,3'-Diindolylmethane is a strong androgen antagonist in human prostate cancer cellsJ Biol Chem.(2003 Jun 6)

42.^Vivar OI1, Lin CL, Firestone GL, Bjeldanes LF3,3'-Diindolylmethane induces a G(1) arrest in human prostate cancer cells irrespective of androgen receptor and p53 statusBiochem Pharmacol.(2009 Sep 1)

43.^Karan D1, Kelly DL, Rizzino A, Lin MF, Batra SKExpression profile of differentially-regulated genes during progression of androgen-independent growth in human prostate cancer cellsCarcinogenesis.(2002 Jun)

44.^Xue L1, Firestone GL, Bjeldanes LFDIM stimulates IFNgamma gene expression in human breast cancer cells via the specific activation of JNK and p38 pathwaysOncogene.(2005 Mar 31)

45.^Saw CL, Cintrón M, Wu TY, Guo Y, Huang Y, Jeong WS, Kong ANPharmacodynamics of dietary phytochemical indoles I3C and DIM: Induction of Nrf2-mediated phase II drug metabolizing and antioxidant genes and synergism with isothiocyanatesBiopharm Drug Dispos.(2011 Jul)

22

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5301182/

Ja, kann sehr helfen.

Es ist kein vollwertiges AI, aber relativ stark.

Nein, das sollte reichen.